RNA-GPS predicts SARS-CoV-2 RNA residency to host mitochondria and nucleolus
Published in Cell systems, 2020
Recommended citation: Wu, K.E., Fazal, F.M., Parker, K.R., Zou, J. and Chang, H.Y., 2020. RNA-GPS predicts SARS-CoV-2 RNA residency to host mitochondria and nucleolus. Cell systems, 11(1), pp.102-108. https://www.sciencedirect.com/science/article/pii/S2405471220302374
SARS-CoV-2 represents a pressing global health crisis; gaining a deeper understanding of its biological mechanisms is key to developing novel therapeutics to mitigate its spread and impact. We find that our prior model for predicting RNA transcript subcellular localization behaviors can be used to make predictions describing how SARS-CoV-2’s viral transcripts behave inside human cells. These predictions have been subsequently experimentally validated in Flynn et al., 2021.